|
KMID : 0352419940130010064
|
|
Keimyung Medical Journal
1994 Volume.13 No. 1 p.64 ~ p.72
|
|
|
Effect of Common Bile Duct Ligation on Liver Xanthine Oxidase activity in Ethanol Intoxicated Rats
|
|
|
|
|
Abstract
|
|
|
The activities of the hepatic and serum xanthine oxidase(XO) were studied in cholestasis induced by common bile duct (CBD) ligation and chronic ethanol intoxication and in cholestasis after acute ethanol intoxication to establish the biochemical
background of alcoholic hazard in hepatobiliary disease.
There were a marked increases in the serum and hepatic XO activities of rats treated with only acute ethanol intoxication. In the group with CBD ligation before acute ethanol intoxication, the activities of hepatic and serum XO increased more
significantly than in the groups with acute etnanol intoxication or in the group with only CBD ligation.
On the other hand, in the group with CBD ligation after chronic ethanol intoxication, the activity of serum XO increased more significantly than in the groups with chronic ethanol intoxication or in the group with only CBD ligation.
Viewed from above results, the hepatic XO seems to be an enzyme which increase its activity in acute ethanol intoxication. And the hepatic XO seems to be an enzyme which increase its activity in acute ethanol intoxication with cholestasis more
than
in
cholestasis; the cause of the increases seems to be the increment of biosynthesis. Especially when the acute and chronic ethanol intoxication with cholestasis occurred, the activity of serum XO was higher than that of the cholestasis because of
increased liver cell damage, which causes the enzyme to leak into the blood in great quantity.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|